Adjusting sampling bias in case-control genetic association studies
نویسندگان
چکیده
منابع مشابه
Adjusting for selection bias in retrospective, case-control studies.
Retrospective case-control studies are more susceptible to selection bias than other epidemiologic studies as by design they require that both cases and controls are representative of the same population. However, as cases and control recruitment processes are often different, it is not always obvious that the necessary exchangeability conditions hold. Selection bias typically arises when the s...
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Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce associations in neuropsychiatry that do not stand the test of time. We studied the processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care...
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Case-control studies of birth defects might be subject to selection bias when there is incomplete ascertainment of cases among pregnancies that are terminated after a prenatal diagnosis of the defect. We propose a simple method to estimate inverse probability of selection weights (IPSWs) for cases ascertained from both pregnancies that end in termination and those that do not end in termination...
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Carbohydrate-metabolizing enzymes may have particularly interesting roles in the honey bee, Apis mellifera , because this social insect has an extremely carbohydrate-rich diet, and nutrition plays important roles in caste determination and socially mediated behavioural plasticity. We annotated a total of 174 genes encoding carbohydrate-metabolizing enzymes and 28 genes encoding lipid-metabolizi...
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BACKGROUND Survival bias is the phenomenon by which individuals are excluded from analysis of a trait because of mortality related to the expression of that trait. In genetic association studies, variants increasing risk for disease onset as well as risk of disease-related mortality (lethality) could be difficult to detect in genetic association case-control designs, possibly leading to underes...
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ژورنال
عنوان ژورنال: Journal of the Korean Data and Information Science Society
سال: 2014
ISSN: 1598-9402
DOI: 10.7465/jkdi.2014.25.5.1127